From literature review, need to include at least the following categories of events
and from AZURE analysis, should include the following
plus any others indicated by the aggregate data extracted from the literature, but unclear what criterion to use to select.
For the AZURE analysis, selected events were those with either estimated odds ratios > 1.5 or risk differences > 0.01 (not considering p-values)
Here the aggregate data are explored with a view to selecting a suitable set of events for more detailed analysis.
Should we select also events with
Are any events that “look important” from the data excluded by the 1.5/0.01 criterion?
Proportions of individuals experiencing each type of event, aggregated over all studies and treatments (including placebo/observation only)
Including only studies where bisphosphonate compared to a control
Standard fixed effects meta analysis
Risk difference and CI, pooled over studies
Lines coloured red are those with either estimated odds ratio > 1.5 or risk difference > 0.01
Odds ratio and CI, pooled over studies
Lines coloured red are those with either estimated odds ratio > 1.5 or risk difference > 0.01